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Intro Video

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Christian Custodio is a student at American Heritage School, Plantation

Abstract

Abstract

Colorectal cancer is a rapidly growing issue today.  The American Cancer Society estimates that about 1 in 21 men and 1 in 23 women in the United States will develop colorectal cancer during their lifetime (American Cancer Society, 4).  The purpose of this study is to see how various groups of interleukin cytokines promote the development of colorectal cancer cells in combination with E. Coli. The hypothesis was that interleukin cytokine 6-A would have the greatest effect on the development of cancerous tumor cells within the CaCo2 cells. In the current study, CaCo2 cells were used to simulate colorectal primary cells within the body. K-12 E. Coli was used along with interleukin cytokine 6A and 13A to research and record the amount of tumor cells produced. The researcher found that all trials in combination with interleukins and E. Coli secretions found an average increase in cell proliferation. IL-4 had the highest cell proliferation rates out of all of the cytokines. IL-13 had the second highest cell proliferation rates. While IL-6 had the lowest cell proliferation rates among the three but still saw an increasing rate from its trials without the E. Coli secretions. The findings of this study can effectively inform researchers how specific cytokines within the colon in combination with E. Coli affect the development of cancer within the colon. It can also provide doctors and medical professionals with information on which bacteria trigger these cytokine immune responses in combination with E. Coli to cause cancer in the colon.

Slideshow

Slideshow

Thank You!

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